The article considers the compliance of a rigid assembly of a steel column of a typical I-section under the loads of an eccentric-compressive load with a random eccentricity.A Vacuums simplified scheme of pinching a rigid hinge is considered as well as its detailed version in which the rigid part of the rod is elaborated as a basement, foundation p
Strong Environmental Filtering Based on Hydraulic Traits Occurring in the Lower Water Availability of Temperate Forest Communities
The trait-based approaches have made progress in understanding the community assembly process.Here, we explore the key traits that may shape community assembly patterns of the same community type but within different water availabilities.Natural Quercus wutaishanica forests were chosen as a suitable study system to test the difference between econo
Ehmt2 inactivation in pancreatic epithelial cells shapes the transcriptional landscape and inflammation response of the whole pancreas
Introduction: The Euchromatic Histone Methyl Transferase Protein 2 (EHMT2), also known as G9a, deposits transcriptionally repressive chromatin marks that play pivotal roles in the maturation and homeostasis of multiple organs.Recently, we have shown that Ehmt2 inactivation in the mouse pancreas alters growth and immune gene expression networks, ant
Sp1 facilitates continued HSV-1 gene expression in the absence of key viral transactivators
ABSTRACT Productive replication of herpes simplex virus (HSV) relies upon a well-ordered transcriptional cascade flowing from immediate-early (IE) to early (E) to late (L) gene products.While several virus-encoded transcriptional activators are involved in this process, IE and E gene promoters also contain multiple binding sites for the ubiquitousl
Drosophila and genome-wide association studies: a review and resource for the functional dissection of human complex traits
Human genome-wide association studies (GWAS) have successfully identified thousands of susceptibility loci for common diseases with complex genetic etiologies.Although the susceptibility variants identified by GWAS usually have only modest effects on individual disease risk, they contribute to a substantial burden of trait variation in the overall